A bone implant with NIR-responsiveness for eliminating osteosarcoma cells and promoting osteogenic differentiation of BMSCs

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 211; p. 112296
• Main Authors: Wu, Zhuangzhuang, Tian, Qiaoqiao, Wang, Jiani, Feng, Yi, Li, Lizhi, Xu, Chaojian, Lv, Jia, Lv, Zhi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2022
• Subjects: Cell Differentiation; Humans; Hyperthermia, Induced; Light-assisted therapy; Multifunctional coating; Osseointegration; Osteogenesis; Osteosarcoma - therapy; Osteosarcoma cells; Prostheses and Implants; Titanium - pharmacology; Light-assisted therapy; Osseointegration; Multifunctional coating; Osteosarcoma cells
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2021.112296

Incomplete removal of tumor cells and insufficient osseointegration are the main causes of bone tumor recurrence and implantation failure. In the present study, a multifunctional titanium-based bioactive implant for near-infrared-triggered synergy therapy to overcome these hurdles is engineered, composed of titanium dioxide (TiO2) nanoparticles doped with fluorine (F)/dopamine (PDA)/collagen. The TiO2 nanoparticles designed in this work can simultaneously exhibit excellent near-infrared-activated photothermal and photocatalytic properties. Besides, the layer designed in this work show excellent anti-tumor activity under irradiation with 808 nm light due to the synergetic effect of hyperthermia and reactive oxygen species (ROS), and Saos-2 cells can be eradicated within 10 min. Moreover, modification of PDA and collagen endue the Ti alloy excellent osteogenic activity. [Display omitted] •Fluorine and TiO2 nano-combination, with photodynamic and photothermal properties.•ROS and heat generated under infrared light irradiation can kill osteosarcoma.•Collagen increases the proliferation of bone marrow mesenchymal stem cells.