Intrinsic functional connectivity in social anxiety disorder with and without comorbid attention deficit hyperactivity disorder

• Published in: Brain research Vol. 1722; p. 146364
• Main Authors: Ergül, Ceylan, Ulasoglu-Yildiz, Cigdem, Kurt, Elif, Koyuncu, Ahmet, Kicik, Ani, Demiralp, Tamer, Tükel, Raşit
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2019
• Subjects: Attention deficit disorder with hyperactivity; Default mode network; Functional connectivity; Functional magnetic resonance imaging; Salience network; Social Phobia; Attention deficit disorder with hyperactivity; Functional connectivity; Functional magnetic resonance imaging; Social Phobia; Default mode network; Salience network
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2019.146364

•Fusiform cortex hypoconnectivity is unique for whole SAD group.•Default mode network hypoconnectivity is related with pure SAD.•Salience network hyperconnectivities are related with comorbid ADHD. Neuroimaging research about social anxiety disorder (SAD) points to hyperactivity in the fear circuit and altered connectivity between the fear circuit and the intrinsic connectivity networks that modulate it. We investigated intrinsic functional connectivity changes in SAD patients by taking into consideration the commonly overlooked comorbidity of attention deficit hyperactivity disorder (ADHD). We compared intrinsic functional connectivity alterations in 16 patients with pure SAD, 18 patients with SAD and comorbid ADHD and 21 healthy controls using seed-to-voxel functional connectivity analyses. Hypoconnectivity of the right fusiform gyrus with the left lingual gyrus was the unique difference between whole SAD group and healthy controls, while in the pure SAD group the fusiform gyrus displayed hypoconnectivity with the posterior default mode network (DMN) regions. In contrast, ADHD comorbidity was associated with hyperconnectivities of the salience network (SN) with the fusiform cortex and the posterior DMN regions, and hyperconnectivities of the posterior DMN with visual, somatosensory and motor cortices. The dichotomic dissociation of the SAD related functional connectivity changes into hypoconnectivities in the pure SAD group vs hyperconnectivities in the SAD-ADHD group leads also to the question, whether ADHD treatment can be considered an alternative for selected SAD cases.