New Lipo-Phosphoramidates for Gene Delivery

Lipo-phosphoramidates constitute an interesting class of synthetic vectors for gene delivery. A structure-activity relationship study points out that the incorporation of the linoleyl polyunsaturated lipid chains produces efficient vectors for gene delivery in the lung. In addition, neutral lipo-pho...

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Published inPhosphorus, sulfur, and silicon and the related elements Vol. 186; no. 4; pp. 918 - 920
Main Authors Jaffrès, Paul-Alain, Fraix, Aurore, Lorilleux, Christophe, Berchel, Mathieu, Couthon-Gourvès, Hélène, Haelters, Jean-Pierre, Yaouanc, Jean-Jacques, Burel, Laure, Giamarchi, Philippe, Midoux, Patrick, Montier, Tristan, Lehn, Pierre
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis Group 31.03.2011
Taylor & Francis Ltd
Taylor & Francis
Subjects
Cationic lipids
Chemical Sciences
gene delivery
Genes
Lipids
phospholipids
phosphoramides
transfection
gene delivery
phosphoramides
lipids
phospholipids
transfection
Cationic lipids
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Summary:Lipo-phosphoramidates constitute an interesting class of synthetic vectors for gene delivery. A structure-activity relationship study points out that the incorporation of the linoleyl polyunsaturated lipid chains produces efficient vectors for gene delivery in the lung. In addition, neutral lipo-phosphoramidates possessing an imidazole motif in the polar head region have been successfully employed in association with a cationic lipophosphoramide to improve in vitro transfection efficiencies. Our recent achievements on this topic are briefly summarized here.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2010.522639