Dosimetric evaluation of radiopharmaceuticals in kidneys and uterine wall of a woman with early pregnancy using Stabin/Segars representations

• Published in: Applied radiation and isotopes Vol. 176; p. 109888
• Main Authors: Vasquez -Arteaga, Marcial, Vega-Carrillo, Hector Rene, Carlos Saavedra, L., Carlos Rodriguez, B., Huber Rodriguez, N., Roger Chanduvi, C., Marcela Vasquez, S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2021
• Subjects: Dosimetry; Female; Humans; Kidney - metabolism; Kidneys; Phantoms, Imaging; Pregnancy; Pregnancy Trimester, First; Radiopharmaceuticals - pharmacokinetics; Segars/Stabin representations; Tissue Distribution; Uterine wall; Uterus - metabolism; Segars/Stabin representations; Uterine wall; Kidneys; Dosimetry
• ISSN: 0969-8043; 1872-9800
• DOI: 10.1016/j.apradiso.2021.109888

MIRD method with the Stabin/Segars anthropomorphic representations were used to calculate the absorbed doses in kidneys and uterine wall of an early-stage pregnant woman when 99mTc (DTPA), 99mTc (DMSA) and 99mTc (MAG3) are used for renal studies. Stabin and Segars anatomical representations are phantoms that are used in Monte Carlo calculations to determine the SAF, that with the pharmaceutical residence time are used to calculate the absorbed dose, from source organs, on target organs. Concerns about the impact on the absorbed dose due to the use of the three 99mTc-based compounds as well as the use of different phantoms were here treated for the case of a female at early pregnant state. The lowest absorbed dose in the kidneys was obtained with 99mTc (MAG3), and the relative difference of using Stabin and Segars anthropomorphic representations was 2.5%. For bladder and rest of organs the relative difference 14.63%. The lowest absorbed dose by uterine wall was obtained with 99mTc(DMSA), however the relative difference of using Stabin and Segars anthropomorphic representations was 12%. •DTPA, DMSA, and MAG3 compounds labeled with 99mTc are used for renal studies.•MIRD methodology is used to calculate the absorbed doses in kidneys and other organs.•The SAF for adult and child, male and female, phantoms (Stabin/Segars) are used in MIRD.•The absorbed doses due to 99mTc compounds in an early pregnant patient were calculated.•The impact on the absorbed dose of using Stabin or Segars representations was determined.