Antitumour activity of Lycium chinensis polysaccharides in liver cancer rats

In the present study, polysaccharides were extracted from the Lycium chinensis (LCP). Rats were divided into four groups. Two groups (Groups A) were maintained on the basal diet, whereas the remaining three groups (Groups B, C and D) had free access to the basal diet and were orally fed with LCP at...

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Published inInternational journal of biological macromolecules Vol. 51; no. 3; pp. 314 - 318
Main Authors Cui, BoKang, Chen, YanFeng, Liu, Su, Wang, Jun, Li, ShuHong, Wang, QiBo, Li, ShengPing, Chen, MinShan, Lin, XiaoJun
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2012
Subjects
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacology
Chemical analysis
Cyclin D1
Cyclin D1 - metabolism
HPLC
Liver - drug effects
Liver - metabolism
Liver Neoplasms, Experimental - metabolism
Lycium - chemistry
Lycium chinensis polysaccharides
Polysaccharides - administration & dosage
Polysaccharides - pharmacology
Rats
Rats, Sprague-Dawley
Spleen - drug effects
Spleen - metabolism
Thymus Gland - drug effects
Thymus Gland - metabolism
Vascular Endothelial Growth Factor A - metabolism
VEGF
Lycium chinensis polysaccharides
Chemical analysis
Cyclin D1
VEGF
HPLC
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Summary:In the present study, polysaccharides were extracted from the Lycium chinensis (LCP). Rats were divided into four groups. Two groups (Groups A) were maintained on the basal diet, whereas the remaining three groups (Groups B, C and D) had free access to the basal diet and were orally fed with LCP at 200mg/kg b.w. for Group B, 400mg/kg b.w. for Group C and 600mg/kg b.w. for Group D, respectively. Following 4 weeks of this dietary regimen, hepatocarcinogenesis was initiated in all animals by a single intraperitoneal DENA (Sigma–Aldrich, St. Louis, MO, USA) injection at a dose of 200mg/kg body weight (mixed with peanut oil). Results still showed that L. chinensis polysaccharides (LCP) increased spleen, thymus indexs, antioxidant enzymes activities and decreased oxidative injury. In addition, LCP still significantly affect VEGF and Cyclin D1 proteins expression in liver cancer rats. It can be concluded that LCP exhibited remarkable protective effects against diethylnitrosamine (DEN)-induced oxidative hepatic injury in liver cancer rats.
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ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2012.05.004