Manganese level and cognitive decline in older adults with the APOE e4 allele: a preliminary study

• Published in: Psychiatry research Vol. 327; p. 115403
• Main Authors: Kim, Shin Gyeom, Choe, Young Min, Suh, Guk-Hee, Lee, Boung Chul, Choi, Ihn-Geun, Kim, Hyun Soo, Hwang, Jaeuk, Keum, Mu-Sung, Yi, Dahyun, Kim, Jee Wook
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.09.2023
• Subjects: APOE4; Cognition; Manganese; APOE4; Cognition; Manganese
• ISSN: 0165-1781; 1872-7123
• DOI: 10.1016/j.psychres.2023.115403

•Manganese has proposed as a new clue to understand the cognitive decline in Alzheimer's disease (AD).•The apolipoprotein e ε4 allele (APOE4) is a well-documented genetic risk factor for AD, however, the role of the APOE4 in this relationship is poorly understood.•APOE4 has a significant moderating effect on the association between serum manganese level and AD-related cognitive decline.•An association between serum manganese level and cognitive decline was significant only in older adults with APOE4-positive, and not in those with APOE4-negative.•APOE4 status should be considered a key component in the design of studies of AD and related cognitive decline that include manganese imbalance as a risk factor. This study examined the relationship between serum manganese level and cognition, and the moderating effect of apolipoprotein E ε4 (APOE4) on this relationship. A total of 164 non-demented participants underwent clinical assessments including serum manganese level and cognition [episodic memory score (EMS), non-memory score (NMS) for executive function/attention/language/ visuospatial skill, and total score (TS)]. Serum manganese × APOE4 interaction had a significant effect on EMS and TS. Serum manganese level was inversely associated with EMS and TS in APOE4-positive but not APOE4-negative participants. APOE4 should be considered a key component in Alzheimer's disease studies that included manganese imbalance as a risk factor.