Evidence That a Positive Modulator of AMPA-Type Glutamate Receptors Improves Delayed Recall in Aged Humans

• Published in: Experimental neurology Vol. 145; no. 1; pp. 89 - 92
• Main Authors: Lynch, Gary, Granger, Richard, Ambros-Ingerson, Jose, Davis, C.Mike, Kessler, Markus, Schehr, Robert
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.05.1997; Elsevier
• Subjects: Aged; Aging - physiology; Biological and medical sciences; Blood Pressure; Dioxoles - administration & dosage; Dioxoles - blood; Glutamatergic system (aspartate and other excitatory aminoacids); Heart Rate; Humans; Male; Medical sciences; Mental Recall - drug effects; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Nootropic Agents - administration & dosage; Nootropic Agents - blood; Pharmacology. Drug treatments; Piperidines - administration & dosage; Piperidines - blood; Psychometrics; Receptors, AMPA - agonists; Receptors, AMPA - physiology; Time Factors; Human; Heart rate; Modulator; AMPA receptor; Memory; Piperidine derivatives; Oral administration; Glutamate receptor; Blood pressure; Biological effect; Psychological effect; Elderly
• ISSN: 0014-4886; 1090-2430
• DOI: 10.1006/exnr.1997.6447

Elderly subjects (65–76 years) were tested for recall of nonsense syllables prior to and after oral administration of 1-(quinoxalin-6 ylcarbonyl)piperidine (CX516), a centrally active drug that enhances currents mediated by AMPA-type glutamate receptors. A significant and positive drug effect was found for delayed (5 min) recall at 75 min posttreatment; average scores for the highest dose group were more than twofold greater than for the placebo group. The drug had no evident influence on heart rate or self-assessment of several psychological variables.