First-episode schizophrenia is associated with a reduction of HERV-K methylation in peripheral blood
•Lower levels of HERV-K methylation were found in first-episode schizophrenia compared to controls.•Multiple-episode schizophrenia patients and controls had similar levels of HERV-K methylation.•Deficit and non-deficit schizophrenia patients and controls had similar levels of HERV-K methylation.•The...
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Published in | Psychiatry research Vol. 271; pp. 459 - 463 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier B.V
01.01.2019
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Subjects | |
Online Access | Get full text |
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Summary: | •Lower levels of HERV-K methylation were found in first-episode schizophrenia compared to controls.•Multiple-episode schizophrenia patients and controls had similar levels of HERV-K methylation.•Deficit and non-deficit schizophrenia patients and controls had similar levels of HERV-K methylation.•There was a significant positive correlation between chlorpromazine equivalent dosage and HERV-K methylation in multiple-episode schizophrenia patients.
Human endogenous retroviruses (HERV) have been widely associated with schizophrenia etiology. Aberrant epigenetic processes may play a role in the etiology of schizophrenia. In this study, we tested whether schizophrenia patients at different stages of illness might present alterations in the levels of HERV-K methylation. We recruited 49 first-episode schizophrenia (FES) patients with 47 age- and sex-matched healthy controls (HCs), and 100 multi-episode schizophrenia (MES) patients with 50 age- and sex-matched HCs. Based on the Schedule for Deficit Schizophrenia, patients with MES were also divided into two subgroups: deficit (D-SCZ) and non-deficit schizophrenia (ND-SCZ). DNA methylation levels of HERV-K sequences were examined in peripheral blood leukocytes. We found significantly lower levels of HERV-K methylation in FES patients compared to HCs. Patients with MES and matched HCs had similar levels of HERV-K methylation. There was a significant positive correlation between chlorpromazine equivalent dosage and HERV-K methylation levels in MES patients, but not in FES individuals. No significant differences in HERV-K methylation levels between D-SCZ and ND-SCZ as well as HCs were found. Our results indicate lower HERV-K methylation levels at early stages of schizophrenia. This difference might normalize with subsequent exacerbations of schizophrenia, likely due to the effects of antipsychotics. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0165-1781 1872-7123 |
DOI: | 10.1016/j.psychres.2018.12.012 |