Plasma LEAP2 concentration is associated with attention and cognitive responses to low-calorie food cues in men depending on body weight status

• Published in: Physiology & behavior Vol. 301; p. 115049
• Main Authors: Andreoli, María F., De Francesco, Pablo N., Titova, Olga E., Perello, Mario, Schiöth, Helgi B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2025
• Subjects: Attention; Feeding behavior; LEAP2; GHSR; Feeding behavior; LEAP2; CI; Attention; ANT; OW; NW; IQR; OB; IGT; LC; HC; BMI
• ISSN: 0031-9384; 1873-507X; 1873-507X
• DOI: 10.1016/j.physbeh.2025.115049

•Plasma LEAP2 is linked to executive and alerting attention in ANT test in lean men.•Plasma LEAP2 associates with Stroop performance on low-calorie cues in men with OW/OB.•Plasma LEAP2 is associated with cognition and attention based on weight status. The putative role of LEAP2 in central nervous system functions such as attentional or cognitive processes related to food intake remain poorly understood in humans. To investigate the relationship between fasting LEAP2 concentration and attentional or cognitive processes related to food cues, and whether body weight status may modulate them. Stroop-Food and Stroop Low-Calorie/High-Calorie food tasks, Attention-Network-Test, Iowa-Gambling-Task, and fasting LEAP2 concentration were assessed in 108 men aged 18–40 yr with normal weight (NW) and 91 with overweight or obesity (OW/OB). Multivariable linear regression analyses were conducted to examine the relationship between fasting LEAP2 concentration and behavioral tests outcomes. Individuals with OW/OB exhibited lower number of correctly identified words in the Stroop Food and Stroop Low-Calorie/High-Calorie Food tasks and had higher LEAP2 concentrations compared to NW participants (p < 0.01). Fasting LEAP2 was positively associated with Executive attention [Beta (95 % CI): 21.18 (2.91, 39.45), p = 0.024], and inversely with Alerting attention [Beta (95 % CI):18.04 (-35.52, -0.57), p = 0.043], in NW but not in subjects with OW/OB. LEAP2 was positively related with responses to low-calorie food words [Beta (95 % CI): 11.88 (0.52, 23.25), p = 0.041] only in subjects with OW/OB. LEAP2 is associated with attention and cognitive responses in men depending on body weight status. It may play a differential role in cognitive processes related to food intake, particularly in individuals with OW/OB while influencing attentional processes in lean subjects. This study was registered at clinicaltrials.gov as NCT01863212. https://clinicaltrials.gov/study/NCT01863212