Cytotoxic 5-Hydroxyindole Alkaloids from the Marine Sponge Scalarispongia sp

Three new 5‐hydroxyindole alkaloids (1, 2, 3) along with seven known analogs (4, 5, 6, 7, 8, 9, 10) were isolated from a Dokdo marine sponge Scalarispongia sp. The elucidation of the structures of the new compounds by spectroscopic analyses indicated that these compounds were an indole glyoxylate (1...

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Published inJournal of heterocyclic chemistry Vol. 50; no. 6; pp. 1400 - 1404
Main Authors Lee, Yeon-Ju, Lee, Dong-Geun, Rho, Hyun Soo, Krasokhin, Vladimir B., Shin, Hee Jae, Lee, Jong Seok, Lee, Hyi-Seung
Format Journal Article
LanguageEnglish
Published HOBOKEN Blackwell Publishing Ltd 01.11.2013
Wiley
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Organic
Marine
Physical Sciences
Scalarispongia
Science & Technology
HYRTIOS
DRUG LEADS
SPONGOSORITES SP
NATURAL-PRODUCTS
A-C
BISINDOLE ALKALOIDS
ANNELATED INDOLE SERIES
INHIBITORS
BIS
DERIVATIVES
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Summary:Three new 5‐hydroxyindole alkaloids (1, 2, 3) along with seven known analogs (4, 5, 6, 7, 8, 9, 10) were isolated from a Dokdo marine sponge Scalarispongia sp. The elucidation of the structures of the new compounds by spectroscopic analyses indicated that these compounds were an indole glyoxylate (1), a mono‐indole analog of hyrtinadine A (2), and a symmetrical bis‐indole with pyridine linker (3). The comparison of IC50 values for obtained compounds against a human leukemia cell line revealed that the bis‐indole structure is a requirement for cytotoxicity.
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ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1599