Beta‐cell dysfunctions and insulin resistance in subjects with increased risk for type 2 diabetes mellitus

• Published in: Journal of cellular and molecular medicine Vol. 4; no. 4; pp. 277 - 282
• Main Authors: Lichiardopol, R., Mirodon, Zenaida
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2000; John Wiley & Sons, Inc
• Subjects: Beta cells; Diabetes; Diabetes mellitus (non-insulin dependent); Glucose; Glucose tolerance; Insulin resistance; insulin secretion; insulin sensitivity; pathogenesis; Sensitivity analysis; type 2 diabetes mellitus
• ISSN: 1582-1838; 1582-4934; 1582-4934
• DOI: 10.1111/j.1582-4934.2000.tb00127.x

The aim of this study was to test if a beta‐cell defect is associated to deterioration of glucose tolerance early during the natural history of the type 2 diabetes mellitus. In 41 overweight women, with macrosomic infants in their antecedent deliveries, measures of insulin response and insulin sensitivity were derived from a short (45 min) iv glucose test. The early (EIR) and the late (LIR) phase insulin responses and the insulin sensitivity index (Si) were calculated. According the response to 75 g oral glucose test the subjects were divided into two groups: Imparired glucose tolerance (IGT;n = 12), and normal glucose tolerance (NGT; n = 29). EIR was reduced in IGT group (14.9 ± 3.6 vs 37.0 ± 4.0; p< 0.002). Glucose tolerance during oral glucose tolerance test (OGTT), correlated inversly to EIR (r=‐0.45; n=41; p< 0.01). A strong correlation of EIR to LIR (r=0.88; n = 41; p< 0.001) but no correlation between glucose tolerance and Si was found.