Prediction of torsade de pointes from the QT interval: analysis of a case series of amisulpride overdoses

Electrocardiograms (ECGs) from a case series of 86 amisulpride overdose events in 66 patients were reviewed for abnormal QT intervals and torsade de pointes (TdP). Eight patients exhibited TdP. In this investigative case series, the magnitude of prolongation of the QT interval was a stronger predict...

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 90; no. 2; p. 243
Main Authors Joy, J P, Coulter, C V, Duffull, S B, Isbister, G K
Format Journal Article
LanguageEnglish
Published United States 01.08.2011
Subjects
Adolescent
Adult
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - poisoning
Dose-Response Relationship, Drug
Drug Overdose
Electrocardiography
Female
Humans
Long QT Syndrome - chemically induced
Male
Middle Aged
Prospective Studies
Severity of Illness Index
Sulpiride - administration & dosage
Sulpiride - analogs & derivatives
Sulpiride - poisoning
Torsades de Pointes - chemically induced
Young Adult
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Summary:Electrocardiograms (ECGs) from a case series of 86 amisulpride overdose events in 66 patients were reviewed for abnormal QT intervals and torsade de pointes (TdP). Eight patients exhibited TdP. In this investigative case series, the magnitude of prolongation of the QT interval was a stronger predictor of TdP than the mere presence of a prolongation per se.
ISSN:1532-6535
DOI:10.1038/clpt.2011.107