Phenolic Acid Derivatives from Ficus esquiroliana Levl. and Their Anti‐Inflammatory Effects

One new mesomer, ficusnaph A (1), two new phenolic acid derivatives, ficusnaphs B and C (2 and 3) together with three known biogenetically related polysubstituted naphthalene derivatives (4–6) were isolated from the stems of Ficus esquiroliana Levl. The structures of these compounds were elucidated...

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Published inChemistry & biodiversity Vol. 20; no. 12; pp. e202301326 - n/a
Main Authors Dai, De‐Cai, Xu, Xue‐Feng, Yan, Hao, Zhang, Yu
Format Journal Article
LanguageEnglish
Published Switzerland Wiley Subscription Services, Inc 01.12.2023
Subjects
anti-inflammatory
Ficus
Ficus esquiroliana
ficusnaph
Inflammation
Lipopolysaccharides
Macrophages
Moraceae
Naphthalene
Nitric oxide
Phenolic acids
Phenols
polysubstituted naphthalene derivatives
Ficus esquiroliana
anti-inflammatory
Moraceae
ficusnaph
polysubstituted naphthalene derivatives
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Summary:One new mesomer, ficusnaph A (1), two new phenolic acid derivatives, ficusnaphs B and C (2 and 3) together with three known biogenetically related polysubstituted naphthalene derivatives (4–6) were isolated from the stems of Ficus esquiroliana Levl. The structures of these compounds were elucidated using comprehensive spectroscopic methods. Compounds 1–6 were evaluated the inhibitory activities against the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW264.7 cells in vitro. Compounds 1 and 2 showed significant inhibitory activity with the IC50 value of 3.12±0.14 and 7.66±0.18 μM, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202301326