Preparation, evaluation, and in vitro release of folic acid conjugated O-carboxymethyl chitosan nanoparticles loaded with methotrexate
To improve the targeted effect and reduce the neurotoxicity of methotrexate (MTX), folic acid (FA)‐conjugated O‐carboxymethyl chitosan (O‐CMC) nanoparticles loaded with MTX were prepared via a crosslinking reaction between the carboxyl groups of O‐CMC and Ca2+ ions. MTX‐loaded FA–chitosan (CS) nanop...
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Published in | Journal of applied polymer science Vol. 125; no. S2; pp. E208 - E215 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
25.09.2012
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | To improve the targeted effect and reduce the neurotoxicity of methotrexate (MTX), folic acid (FA)‐conjugated O‐carboxymethyl chitosan (O‐CMC) nanoparticles loaded with MTX were prepared via a crosslinking reaction between the carboxyl groups of O‐CMC and Ca2+ ions. MTX‐loaded FA–chitosan (CS) nanoparticles as controls were also prepared. The chemical structure of FA‐conjugated O‐CMC (FA–O‐CMC) was confirmed by 1H‐NMR and Fourier transform infrared spectroscopy. The results show that the obtained FA–O‐CMC nanoparticles were spherical in shape with a narrow size distribution. The encapsulation efficiency and loading capacity of MTX in the FA–O‐CMC nanoparticles were higher than those in the FA–CS nanoparticles, and the particle size of the FA–O‐CMC nanoparticles were also smaller than that of the control. In vitro release studies indicated that the release of MTX from FA–O‐CMC nanoparticles was slower in the initial period, but the cumulative release was much higher. FA was also released from the nanoparticles; this might prove to be a potential antidote for preventing the neurotoxicity caused by MTX. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012 |
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Bibliography: | Key Scientific and Technological Projects of Chongqing Science and Technology Commission - No. CSTC2010AC5050 ark:/67375/WNG-XGH3MHWG-H ArticleID:APP36556 istex:C707524B3406279F696F0A53F34C8A4C963DAB19 Fundamental Research Funds for the Central Universities of China - No. CDJXS10220008 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0021-8995 1097-4628 |
DOI: | 10.1002/app.36556 |