The effect of hepatic blood inflow occlusion on hepatic cancer treated with diode-laser thermocoagulation

• Published in: Journal of Zhejiang University. B. Science Vol. 6; no. 4; pp. 232 - 235
• Main Author: 洪德飞 李松英 童利民 陈斌 彭淑牖
• Format: Journal Article
• Language: English
• Published: China Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China%Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310006, China%State Key Laboratory of Silicon Marterial, Zhejiang University, Hangzhou 310027, China 01.04.2005; Zhejiang University Press
• Subjects: Animals; Biomedicine; Laser Coagulation; Liver Circulation - physiology; Liver Neoplasms - blood supply; Liver Neoplasms - surgery; Rats; Temperature; Time Factors; 激光治疗; 肝脏血液; 血管闭塞; Laser/diode-laser; Hepatic blood inflow/occlusion; Hepatic carcinoma/thermotherapy
• ISSN: 1673-1581; 1862-1783
• DOI: 10.1631/jzus.2005.B0232

Objective: To assess the effect of temporary occlusion of hepatic blood inflow on hepatic cancer treated with diode-laser induced thermocogation (LITT). Methods: The carcinoma Walker-256 was implanted in 40 SD rat livers. Twelve days later, the animals were randomly divided into 4 groups. Group A received LITT alone; group B received hepatic artery temporary occlusion during LITT; group C received portal vein temporary occlusion during LITT; group D received hepatic artery and portal vein temporary occlusion during LITT. Tumors were exposed to 810 nm diode-laser light at 0.95 watts for 10 min from a scanner tip applicator placed in the tumor. At the same time, the intrahepatic temperature distribution in rats with liver tumors was measured per 2 min during thermocoagulation. Tumor control was examined immediately 7 and 14 d after thermocoagulation. Results: There was significant difference of intrahepatic temperature distribution in rats with liver tumors among the 4 groups (P<0.05) except when group C samples were compared with group D samples at each time point, and group B samples were compared with group C samples at 120 s (P>0.05). Light microscopic examination of the histologic section samples revealed three separate zones: regular hyperthermic coagulation necrosis zone, transition zone and reference zone. Compared with the samples in group A and group B, group C and group D samples had more clear margin among the three zones. Conclusion: The hepatic blood inflow occlusion, especially portal vein hepatic blood inflow occlusion, or all hepatic blood inflow occlusion considerably increased the efficacy of LITT in the treatment of liver cancer.