Programming of the Beige Phenotype in White Adipose Tissue of Adult Mice by Mild Resveratrol and Nicotinamide Riboside Supplementations in Early Postnatal Life

• Published in: Molecular nutrition & food research Vol. 62; no. 21; pp. e1800463 - n/a
• Main Authors: Serrano, Alba, Asnani-Kishnani, Madhu, Rodríguez, Ana María, Palou, Andreu, Ribot, Joan, Bonet, María Luisa
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.11.2018
• Subjects: Adiponectin; Adipose tissue; Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - physiology; Adipose Tissue, White - drug effects; Adipose Tissue, White - physiology; Age Factors; Animals; Animals, Newborn; Body weight; Body Weight - drug effects; Body weight gain; Diet; Diet, High-Fat - adverse effects; Dietary Supplements; Energy balance; Female; Fuel consumption; Gene expression; Gene Expression Regulation - drug effects; Genotype & phenotype; High fat diet; Lactation; Leptin; Long-term effects; Male; metabolic programming; Mice; Mice, Inbred Strains; Niacinamide - analogs & derivatives; Niacinamide - pharmacology; Nicotinamide; nicotinamide riboside; Parameters; Phenotype; Phenotypes; Resveratrol; Resveratrol - pharmacology; Rodents; Thermogenesis - drug effects; Thermogenesis - genetics; Transcription; adipose tissue; nicotinamide riboside; resveratrol; metabolic programming
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.201800463

Scope Resveratrol (RSV) and nicotinamide riboside (NR) are food compounds with anti‐obesity actions in adult rodents. Here, the long‐term effects of RSV and NR mild supplementation throughout lactation on adiposity‐related parameters and the appearance of the beige phenotype in white adipose tissue (WAT) in adulthood are assessed. Methods and results Newborn mice received orally RSV or NR from day 2 to 20 of life. Control littermates received the vehicle. All animals are weaned onto a chow diet on day 21. On day 90, half the animals of each group are assigned to a high‐fat diet (HFD) for 10 weeks, while the other remained on a normal‐fat diet. Energy‐balance‐related parameters, blood parameters, and gene expression and immunohistochemical analysis of WAT are assessed. Treated male mice show an improved response to the HFD, such as delayed body weight gain, a blunted increase in the plasma leptin/adiponectin ratio, and a decreased lipolytic response, together with signs of white‐to‐brown fat remodeling in inguinal WAT. These effects are absent in female mice. Conclusion RSV and NR supplementations in early postnatal life affect WAT's thermogenic/oxidative transcriptional phenotype and metabolic responses in adulthood, with upregulatory and beneficial effects evidenced in male animals. Resveratrol (RSV) and nicotinamide riboside (NR) are food compounds with an anti‐obesity action in adult rodents. However, their activity in the early programming of adipose tissue features remains largely unknown. Here, it is shown that mild neonatal supplementation of RSV and NR exert programming effects on the thermogenic/oxidative transcriptional phenotype of adipose tissues and on the response to a high fat diet in adulthood in mice, with particular benefits in male mice.