Mushroom‐Mediated Redox Reactions

• Published in: Chemistry : a European journal Vol. 31; no. 2; pp. e202403010 - n/a
• Main Author: Yang, Yan‐Long
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 09.01.2025
• Subjects: Agaricales - chemistry; Agaricales - metabolism; Aliphatic compounds; Alkenes; Alkenes - chemistry; Alkenes - metabolism; Aromatic compounds; Biocatalysis; Biocatalysts; Carboxylic acids; Carboxylic Acids - chemistry; Carboxylic Acids - metabolism; Chemical reactions; Chemical synthesis; C−H oxidation; Enzymes; Epoxidation; Hydroxylation; Ketones; Ketones - chemistry; Ketones - metabolism; Metabolites; Mushroom; Mushrooms; Oxidation-Reduction; p450s; Redox reactions; Reduction; C−H oxidation; Reduction; Biocatalysis; p450s; Mushroom
• ISSN: 0947-6539; 1521-3765; 1521-3765
• DOI: 10.1002/chem.202403010

The application of biocatalysts in organic synthesis has grown significantly in recent years, and both academia and industry are continuously searching for novel biocatalysts capable of performing challenging chemical reactions. Mushrooms are a rich source of ligninolytic and secondary metabolite biosynthetic enzymes, and therefore were considered promising biocatalysts for organic synthesis. This review focuses on the broad utilization potential of mushroom‐based biocatalysts and highlights key advances in mushroom‐mediated redox reactions. It mainly includes the reduction of ketones and carboxylic acids, hydroxylation of aromatic and aliphatic compounds, epoxidation of olefins, oxidative cleavage of alkenes, and other uncommon reactions catalyzed by the whole cells or purified enzymes of mushroom origin. Overall, a comprehensive overview of the applications of mushrooms as biocatalysts in organic synthesis is provided, which puts this versatile microorganism in the spotlight of further research. Mushroom is a rich source of enzymes and therefore is a promising biocatalyst for organic synthesis. This review highlights key advances in mushroom‐mediated redox reactions using whole cells, purified enzymes or recombinant enzymes, including the reduction of carbonyl compounds and carboxylic acids, oxidation of C−H bonds, epoxidation of olefins and oxidative cleavage of alkenes.