Clarithromycin induced torsade de pointes

Background Clarithromycin is a commonly used macrolide antibiotic. It is known to cause QT prolongation. Medication induced QT prolongation is a major risk factor for the development of torsade de pointes. Methods A 79-year-old lady presented with frequent episodes of torsade de pointes following co...

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Bibliographic Details
Published inIrish journal of medical science Vol. 177; no. 1; pp. 67 - 68
Main Authors Hensey, C., Keane, D.
Format Journal Article
LanguageEnglish
Published London Springer-Verlag 01.03.2008
Subjects
Adrenergic beta-Antagonists - therapeutic use
Aged, 80 and over
Anti-Bacterial Agents - adverse effects
Case Report
Clarithromycin - adverse effects
Electrocardiography
Family Medicine
Female
General Practice
Humans
Internal Medicine
Medicine
Medicine & Public Health
Pacemaker, Artificial
Torsades de Pointes - chemically induced
Torsades de Pointes - diagnosis
Torsades de Pointes - therapy
Medication
QT interval
Clarithromycin
Acquired
Torsade de pointes
Prolongation
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Summary:Background Clarithromycin is a commonly used macrolide antibiotic. It is known to cause QT prolongation. Medication induced QT prolongation is a major risk factor for the development of torsade de pointes. Methods A 79-year-old lady presented with frequent episodes of torsade de pointes following commencement of clarithromycin. This was noted to be in association with a prolongation of the QT interval. Conclusion Knowledge of medications which prolong the QT interval is important to minimize the risk of ventricular arrhythmias, which may lead to sudden death. This is essential in patients with a congenitally long QT interval.
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-007-0057-3