Role of sulfur chirality in the chemical processes of biology

Chiral structures profoundly influence chemical and biological processes. While chiral carbon biomolecules have received much attention, chirality is also possible in certain sulfur compounds; just as with carbon, there can be differences in the physiological behavior of chiral sulfur compounds. For...

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Bibliographic Details
Published inChemical Society reviews Vol. 34; no. 7; p. 609
Main Author Bentley, Ronald
Format Journal Article
LanguageEnglish
Published England 01.01.2005
Subjects
Biology
Chelating Agents - chemistry
Chelating Agents - metabolism
Molecular Conformation
Stereoisomerism
Sulfur Compounds - chemistry
Sulfur Compounds - metabolism
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Summary:Chiral structures profoundly influence chemical and biological processes. While chiral carbon biomolecules have received much attention, chirality is also possible in certain sulfur compounds; just as with carbon, there can be differences in the physiological behavior of chiral sulfur compounds. For instance, one drug enantiomer, Nexium (esomeprazole, a chiral sulfoxide), is used for its superior clinical properties as a proton pump inhibitor over the racemic mixture, Prilosec (Losec, omeprazole). This critical review introduces sulfur stereochemistry and nomenclature, and provides a comprehensive approach to chiral sulfur compounds and their enzymatic reactions in general and secondary metabolism. The major structural types of biological interest are sulfonium salts, sulfoxides, and sulfoximines. (103 references).
ISSN:0306-0012
1460-4744
DOI:10.1039/b418284g