Non-beta-adrenergic-mediated peripheral circulatory hyperkinesia in hyperthyroidism

Systolic time intervals and brachial circulation, evaluated by pulsed Doppler in terms of arterial diameter, blood velocity and flow, and vascular resistance, were studied in 12 hyperthyroid patients and in 12 normal controls. In patients, arterial circulation was studied before and during mechanica...

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Published inAngiology Vol. 43; no. 12; p. 996
Main Authors Valensi, P, Simon, A, Pithois-Merli, I, Levenson, J
Format Journal Article
LanguageEnglish
Published United States 01.12.1992
Subjects
Adrenergic beta-Antagonists - pharmacology
Atenolol - pharmacology
Blood Flow Velocity
Blood Pressure
Brachial Artery - physiopathology
Extremities - blood supply
Female
Heart Rate - drug effects
Humans
Hyperthyroidism - blood
Hyperthyroidism - physiopathology
Male
Middle Aged
Propranolol - pharmacology
Sympathetic Nervous System - physiopathology
Thyroid Hormones - blood
Vascular Resistance
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Summary:Systolic time intervals and brachial circulation, evaluated by pulsed Doppler in terms of arterial diameter, blood velocity and flow, and vascular resistance, were studied in 12 hyperthyroid patients and in 12 normal controls. In patients, arterial circulation was studied before and during mechanical exclusion of the hand, and hemodynamic measurements were repeated after beta-blocker treatment and after obtainment of euthyroid state. Compared with controls, patients had higher heart rate (P < 0.001), lower systolic time intervals (P < 0.05, P < 0.01), and higher blood velocity (P < 0.05). Beta blockade decreased heart rate (P < 0.05, P < 0.001) but did not change systolic time intervals and arterial circulation. Euthyroid state decreased heart rate (P < 0.01), preejection period (P < 0.01), and blood velocity (P < 0.01) and flow (P < 0.05). The decreases in velocity and flow before hand exclusion when euthyroid state was obtained were correlated with hyperthyroid values of velocity and flow respectively (r = 0.85, r = 0.90, P < 0.01, P < 0.001). Vascular resistance during hand exclusion was correlated negatively with serum T3 level during hyperthyroid and euthyroid states. Thus, thyroid hormones but not beta-adrenoreceptors participate in the peripheral hyperkinesia of hyperthyroidism.
ISSN:0003-3197
DOI:10.1177/000331979204301206