An Automata-Based Cardiac Electrophysiology Simulator to Assess Arrhythmia Inducibility

• Published in: Mathematics (Basel) Vol. 10; no. 8; p. 1293
• Main Authors: Serra, Dolors, Romero, Pau, Garcia-Fernandez, Ignacio, Lozano, Miguel, Liberos, Alejandro, Rodrigo, Miguel, Bueno-Orovio, Alfonso, Berruezo, Antonio, Sebastian, Rafael
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.04.2022
• Subjects: Ablation; Arrhythmia; Cardiac arrhythmia; cardiac electrophysiology simulation; Cellular automata; Customization; Electrophysiology; Mathematical models; Potassium; Safety factors; Simulation; Tachycardia; therapy planning
• ISSN: 2227-7390; 2227-7390
• DOI: 10.3390/math10081293

Personalized cardiac electrophysiology simulations have demonstrated great potential to study cardiac arrhythmias and help in therapy planning of radio-frequency ablation. Its application to analyze vulnerability to ventricular tachycardia and sudden cardiac death in infarcted patients has been recently explored. However, the detailed multi-scale biophysical simulations used in these studies are very demanding in terms of memory and computational resources, which prevents their clinical translation. In this work, we present a fast phenomenological system based on cellular automata (CA) to simulate personalized cardiac electrophysiology. The system is trained on biophysical simulations to reproduce cellular and tissue dynamics in healthy and pathological conditions, including action potential restitution, conduction velocity restitution and cell safety factor. We show that a full ventricular simulation can be performed in the order of seconds, emulate the results of a biophysical simulation and reproduce a patient’s ventricular tachycardia in a model that includes a heterogeneous scar region. The system could be used to study the risk of arrhythmia in infarcted patients for a large number of scenarios.