Increased Leptin/Adiponectin Ratio and Free Leptin Index Are Markers of Insulin Resistance in Obese Girls during Pubertal Development

Background: Modifications in body fat in obese patients during puberty determine changes in adipokines that affect insulin sensitivity. Aims: We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) durin...

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Published inHormone research in paediatrics Vol. 80; no. 5; pp. 363 - 370
Main Authors Donoso, M.A., Muñoz-Calvo, M.T., Barrios, V., Martínez, G., Hawkins, F., Argente, J.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.11.2013
Subjects
Adiponectin - blood
Biomarkers - blood
Body Mass Index
Child
Female
Follow-Up Studies
Humans
Insulin Resistance
Leptin - blood
Models, Biological
Obesity - blood
Obesity - physiopathology
Original Paper
Prospective Studies
Puberty - blood
Waist Circumference
Obesity
Puberty
Leptin
Cardiovascular risk
Insulin resistance
Fat mass
Adiponectin
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Summary:Background: Modifications in body fat in obese patients during puberty determine changes in adipokines that affect insulin sensitivity. Aims: We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) during pubertal development. Methods: A prospective study of 32 obese girls (OG) and age-matched control girls (CG) was performed. OG were divided into those that maintained a weight loss (WL) of >1 SD of initial body mass index (BMI) (WL group, n = 25) and those without WL (NWL group, n = 7). Oral glucose tolerance tests (OGTT) were performed to evaluate IR. Correlations of adipokines, L/A, and FLI with BMI, waist circumference, percentage of TBF (%TBF) and IR were performed over pubertal development. Results: The L/A ratio and FLI were increased in OG at baseline. Both indexes decreased in the WL group as puberty progressed, with no change in CG or NWL. In the WL group, a correlation between L/A and FLI with OGTT and %TBF, and L/A and homeostasis model assessment (HOMA) was found throughout the study. Conclusion: The L/A ratio and FLI are good markers to follow changes in IR and %TBF after WL during puberty. Insulin more accurately reflects the changes in IR than HOMA.
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ISSN:1663-2818
1663-2826
DOI:10.1159/000356046