Abnormal IL-1β cytokine expression in the cerebellum of the ataxic mutant mice staggerer and Lurcher
To assess the extent to which interleukin-1β (IL-1β) may contribute to the development and/or progression of neurodegenerative processes, we have examined the levels of IL-1β in the brain of two types of neurological mutant mice, staggerer and Lurcher. Using a quantitative immunological method (enzy...
Saved in:
Published in | Brain research. Molecular brain research. Vol. 62; no. 2; pp. 224 - 227 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
20.11.1998
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | To assess the extent to which interleukin-1β (IL-1β) may contribute to the development and/or progression of neurodegenerative processes, we have examined the levels of IL-1β in the brain of two types of neurological mutant mice,
staggerer and
Lurcher. Using a quantitative immunological method (enzyme-linked immunosorbent assay, ELISA), we measured IL-1β in the cerebellum, hippocampus and cerebral cortex of mutant mice at baseline and after peripheral LPS treatment. Two types of IL-1β expression abnormalities were found in the mutant cerebella: higher basal level in
Lurcher and a response to peripheral administration of LPS in
staggerer. The association of IL-1β expression abnormalities with the only brain structure where a massive neurodegeneration occurs supports the role of proinflammatory cytokines in this process. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0169-328X 1872-6941 |
DOI: | 10.1016/S0169-328X(98)00268-X |