Temperature-Controlled Divergent Synthesis of Pyrazoles and 1-Tosyl-1H-pyrazoles under Transition-Metal-Catalyst- and Oxidant-Free Conditions

Herein, a general and practical temperature-controlled approach for the divergent synthesis of pyrazoles and 1-tosyl-1H-pyrazoles via electrophilic cyclization in the absence of transition-metal catalysts and oxidants was developed. The desired products were obtained in moderate to excellent yields...

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Published inMolecules (Basel, Switzerland) Vol. 29; no. 8; p. 1706
Main Authors Wang, Kai, Xu, Wenjing, Xia, Chengcai, Cao, Xianting
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.04.2024
Subjects
Chromatography
divergent synthesis
Green chemistry
green strategies
Investigations
ionic liquids
Nitrogen
pyrazole derivatives
Solvents
Temperature
temperature-controlled
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Summary:Herein, a general and practical temperature-controlled approach for the divergent synthesis of pyrazoles and 1-tosyl-1H-pyrazoles via electrophilic cyclization in the absence of transition-metal catalysts and oxidants was developed. The desired products were obtained in moderate to excellent yields from common starting materials in both ionic liquids and ethanol by simply tuning the reaction temperature. This strategy employs easily synthesized substrates, mild reaction conditions, and excellent functional-group tolerance.
Bibliography:ObjectType-Article-1
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29081706