Urinary levels of regenerating protein Iα do not differentiate celiac patients and healthy subjects

• Published in: Biomarkers Vol. 18; no. 2; pp. 178 - 180
• Main Authors: Ruíz-Ortiz, Estíbaliz, Santos, Agustín L., Pujol-Autonell, Irma, Planas, Raquel, Montraveta, Montserrat, Pintos, Guillem, Doladé, Maria, Cabré, Eduard, Vives-Pi, Marta
• Format: Journal Article
• Language: English
• Published: England Informa UK, Ltd 01.03.2013; Taylor & Francis
• Subjects: Adolescent; Adult; Autoimmunity; biomarkers; Biomarkers - blood; Biomarkers - urine; Case-Control Studies; Celiac Disease - blood; Celiac Disease - diagnosis; Celiac Disease - urine; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lithostathine - blood; Lithostathine - urine; Male; regeneration
• ISSN: 1354-750X; 1366-5804
• DOI: 10.3109/1354750X.2012.745903

Abstract Celiac disease is an autoimmune disorder induced by gluten in genetically predisposed people. The discovery of new biomarkers may help in the diagnosis and follow-up of celiac patients. Regenerating islet-derived 1 alpha (REGIα) - a biomarker related to tissue regeneration - is increased in serum at the onset of the disease, decreasing after gluten-free diet (GFD). As REGIα is a 18 kDa soluble glycoprotein, it may be detected in urine samples, increasing in celiac patients. We have determined REGIα levels by ELISA. No differences were found among patients (onset or after GFD) and controls and no correlation exists among REGIα in sera and urine.