Recent advances in stimuli responsive hydrogels for oral disease treatment

• Published in: Materials & design Vol. 240; p. 112817
• Main Authors: Wei, Yuzi, Zheng, Lingnan, Xie, Xi, Yang, Xi, Liao, Jinfeng
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.04.2024; Elsevier
• Subjects: Drug delivery system; Oral diseases; Stimuli responsive hydrogels; Stimuli responsive hydrogels; Drug delivery system; Oral diseases
• ISSN: 0264-1275; 1873-4197
• DOI: 10.1016/j.matdes.2024.112817

The classification of stimuli responsive hydrogels and their application in oral diseases. [Display omitted] •The structural formulas of stimuli responsive polymers, the advantages of different types of stimuli responsive hydrogels, and the action mechanisms of stimuli responsive hydrogels are expounded.•The applications of stimuli responsive hydrogels smart drug delivery system in oral disease management are summarized.•Challenges and future prospects of stimuli responsive hydrogels are presented. Oral diseases include oral cancer, periodontitis, endodontium infection, and caries. The oral cavity is prone to the proliferation of pathogenic bacteria and infectious diseases owing to its unique environment. During the drug-based treatment of oral diseases, saliva can dilute the drug formulation, reduce the interaction between the drug and site of action, and weaken drug efficacy. Therefore, searching an effective drug delivery approach is extremely critical and urgent. Stimuli responsive hydrogels respond to altered environmental conditions under disease states, allowing specific drug delivery. Accordingly, smart drug delivery systems can prolong the duration of drug action, reduce adverse reactions, decrease the frequency of administration, and improve patient compliance, thereby accelerating recovery. In this review, we discuss the different types of stimuli responsive hydrogels for smart drug delivery, focusing on their application in oral disease management. Further, we present current challenges and provide suggestions for future research on stimuli responsive hydrogels for oral disease treatment.