Octreotide-Induced Long QT Syndrome in a Child with Congenital Hyperinsulinemia and a Novel Missense Mutation (p.Met115Val) in the ABCC8 Gene

• Published in: Hormone research in paediatrics Vol. 80; no. 4; pp. 299 - 303
• Main Authors: Çelik, Nurullah, Cinaz, Peyami, Emeksiz, Hamdi Cihan, Hussain, Khalid, Çamurdan, Orhun, Bideci, Aysun, Döğer, Esra, Yüce, Özge, Türkyılmaz, Zafer, Oğuz, Ayşe Deniz
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.10.2013
• Subjects: Amino Acid Substitution; Antineoplastic Agents, Hormonal - administration & dosage; Antineoplastic Agents, Hormonal - adverse effects; Congenital Hyperinsulinism - drug therapy; Congenital Hyperinsulinism - genetics; Humans; Infant; Long QT Syndrome - chemically induced; Long QT Syndrome - genetics; Male; Mutation, Missense; Novel Insights from Clinical Practice; Octreotide - administration & dosage; Octreotide - adverse effects; Sulfonylurea Receptors - genetics; Octreotide; Congenital hyperinsulinism; ABCC8; Long QT
• ISSN: 1663-2818; 1663-2826
• DOI: 10.1159/000354666

Background/Aims: Congenital hyperinsulinism (CHI) denotes an inappropriate secretion of insulin from pancreatic β-cells in the presence of a low blood glucose level due to various genetic causes. Diazoxide is the first-line medical treatment for CHI. In case of failure, a somatostatin analogue called octreotide is used. A prolonged QT interval is an unusual side effect of octreotide which can be lethal if unrecognized. Case Presentation: We report on a 35-day-old infant who was diagnosed with CHI on the 3rd day of his life and underwent pancreatectomy due to failure of medical treatment at 8 months. His genetic analysis revealed a compound heterozygosity for a novel missense mutation (p.Met115Val) and a nonsense mutation (p.Trp1339X) in the ABCC8 gene. Furthermore, at the 6th month of follow-up, a long QT (0.49 s) was determined by ECG examination, which was normalized following discontinuation of octreotide treatment after pancreatectomy. Thus, the long QT was considered to be secondary to octreotide medication. Conclusion: We recommend ECG monitoring before and during octreotide treatment in order to recognize a prolonged QT interval and to prevent related complications in cases with congenital hyperinsulinemia.