Microbial invasion of the amniotic cavity is associated with impaired cognitive and motor function at school age in preterm children

• Published in: Pediatric research Vol. 87; no. 5; pp. 924 - 931
• Main Authors: Thorell, Anna, Hallingström, Maria, Hagberg, Henrik, Fyhr, Ing-Marie, Tsiartas, Panagiotis, Olsson, Ingrid, Chaplin, John E, Mallard, Carina, Jacobsson, Bo, Sävman, Karin
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.04.2020
• Subjects: Age; Neurosciences; Neurovetenskaper; Newborn babies
• ISSN: 0031-3998; 1530-0447; 1530-0447
• DOI: 10.1038/s41390-019-0666-3

Chorioamnionitis is an important cause of preterm delivery. Data on neurodevelopmental outcome in exposed infants are inconsistent due to difficulties in diagnosing intrauterine infection/inflammation and lack of detailed long-term follow-up. We investigate cognitive and motor function in preterm infants at early school age and relate the findings to bacteria in amniotic fluid obtained by amniocentesis (microbial invasion of the amniotic cavity (MIAC)) or placenta findings of histological chorioamnionitis (HCA) or fetal inflammatory response syndrome (FIRS). Sixty-six infants with gestational age <34 weeks at birth and without major disabilities were assessed using WISC-III and the Bruininks-Oseretsky Test of Motor Proficiency. Results were corrected for gestational age and sex. Children exposed to MIAC had significantly lower scores for full-scale IQ and verbal IQ compared to the non-MIAC group and the difference in full-scale IQ remained after correction for confounding factors. The MIAC group had also significantly lower motor scores after correction. In contrast, motor function was not affected in infants exposed to HCA or FIRS and differences between groups for cognitive scores were lost after corrections. Exposure to bacteria in amniotic fluid is associated with lower motor and cognitive scores in school age preterm infants without major disabilities.