Flash generation of alpha-(trifluoromethyl) vinyllithium and application to continuous flow three-component synthesis of alpha-trifluoromethylamides

alpha-(Trifluoromethyl)vinyllithium was generated and used for the reaction with electrophiles at -78 degrees C in a flow microreactor although the batch reaction should be carried out at ca. -100 degrees C, and the method was applied to continuous flow three-component synthesis of alpha-trifluorome...

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Published inChemical communications (Cambridge, England) Vol. 50; no. 95; pp. 15079 - 15081
Main Authors Nagaki, Aiichiro, Tokuoka, Shinya, Yoshida, Jun-ichi
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 11.12.2014
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
MICROREACTOR SYNTHESIS
ORGANIC-SYNTHESIS
MULTICOMPONENT REACTIONS
POT
INTEGRATED CHEMICAL-PROCESS
SPACE INTEGRATION
ALLYLIC ALCOHOLS
CHEMISTRY
BUILDING-BLOCK
EFFICIENT
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Summary:alpha-(Trifluoromethyl)vinyllithium was generated and used for the reaction with electrophiles at -78 degrees C in a flow microreactor although the batch reaction should be carried out at ca. -100 degrees C, and the method was applied to continuous flow three-component synthesis of alpha-trifluoromethylamides.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06709f