Effect of botulinum toxin A on proliferation and apoptosis in the T47D breast cancer cell line

The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Bo...

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Published inAsian Pacific journal of cancer prevention : APJCP Vol. 14; no. 2; pp. 891 - 894
Main Authors Bandala, Cindy, Perez-Santos, Jose Luis Martin, Lara-Padilla, Eleazar, Delgado Lopez, Guadalupe, Anaya-Ruiz, Maricruz
Format Journal Article
LanguageEnglish
Published Thailand 01.01.2013
Subjects
Apoptosis - drug effects
Botulinum Toxins, Type A - pharmacology
Breast Neoplasms - drug therapy
Caspase 3 - metabolism
Caspase 7 - metabolism
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Female
Humans
Neuromuscular Agents - pharmacology
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Summary:The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.
ISSN:1513-7368
2476-762X
DOI:10.7314/APJCP.2013.14.2.891