Chemical approach toward efficient DNA methylation analysis

The development of a reaction for the detection of the presence/absence of one methyl group in a very long DNA strand is a chemically and biologically challenging research subject. Several newly designed chemical assays for the typing of DNA methylation are reported and discussed in this paper. A ne...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 7; no. 1; pp. 21 - 26
Main Author Okamoto, Akimitsu
Format Journal Article
LanguageEnglish
Published England 01.01.2009
Subjects
Chemistry - methods
Chromosome Mapping
CpG Islands
Cytosine - chemistry
DNA - chemistry
DNA Methylation
Female
Gene Expression Regulation
Genetic Techniques
Genotype
Humans
Male
Models, Chemical
Oxygen - chemistry
Photosensitizing Agents - chemistry
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Summary:The development of a reaction for the detection of the presence/absence of one methyl group in a very long DNA strand is a chemically and biologically challenging research subject. Several newly designed chemical assays for the typing of DNA methylation are reported and discussed in this paper. A new concept of sequence-specific short-term methylation analysis, supported by a chemical basis, is the starting point for a novel methylation-typing assay, which will supersede conventional methods.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-0520
1477-0539
DOI:10.1039/b813595a