The application with tetramethyl pyrazine for antithrombogenicity improvement on silk fibroin surface

• Published in: Applied surface science Vol. 255; no. 2; pp. 480 - 482
• Main Authors: Lian, Xiaojie, Wang, Song, Xu, Guoliang, Lin, Nini, Li, Qian, Zhu, Hesun
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 15.11.2008; Elsevier
• Subjects: Blood-contacting materials; Chinese herbal medicines; Condensed matter: electronic structure, electrical, magnetic, and optical properties; Condensed matter: structure, mechanical and thermal properties; Cross-disciplinary physics: materials science; rheology; Exact sciences and technology; Physics; Silk fibroin; Tetramethyl pyrazine; 82.45.Mp; Blood-contacting materials; Silk fibroin; Tetramethyl pyrazine; 82.35.Pq; 87.68.+z; Chinese herbal medicines; 87.90.+y; 87.90,+y
• ISSN: 0169-4332; 1873-5584
• DOI: 10.1016/j.apsusc.2008.06.068

Chuanxiongqin (tetramethyl pyrazine, TMPZ) is an active ingredient of the Chinese herb and was used to improve the anticoagulant activity of silk fibroin (SF). The side methyl of TMPZ was oxidized, and then linked to polyacrylic acid (PAA) via an ester bond. The prepared conjugate was further mixed with SF solutions at different ratios to make blend films. The resulting products were characterized by FTIR, UV spectrometer and X-ray photoelectron spectroscopy (XPS). The in vitro antithrombogenicity were evaluated by the activated partial thromboplastin time (APTT) and the prothrombin time (PT). It was shown that blend films had longer coagulation time than the pure SF film.