Metal-catalysed approaches to amide bond formation

Amongst the many ways of constructing the amide bond, there has been a growing interest in the use of metal-catalysed methods for preparing this important functional group. In this tutorial review , highlights of the recent literature have been presented covering the key areas where metal catalysts...

Full description

Saved in:
Bibliographic Details
Published inChemical Society reviews Vol. 4; no. 7; pp. 345 - 3415
Main Authors Allen, C. Liana, Williams, Jonathan M. J
Format Journal Article
LanguageEnglish
Published England 01.01.2011
Subjects
Aldehydes
Amides
Amides - chemistry
Amines
Bonding
Catalysis
Catalysts
Joining
Metals - chemistry
Palladium
Online AccessGet full text

Cover

More Information
Summary:Amongst the many ways of constructing the amide bond, there has been a growing interest in the use of metal-catalysed methods for preparing this important functional group. In this tutorial review , highlights of the recent literature have been presented covering the key areas where metal catalysts have been used in amide bond formation. Acids and esters have been used in coupling reactions with amines, but aldehydes and alcohols have also been used in oxidative couplings. The use of nitriles and oximes as starting materials for amide formation are also emerging areas of interest. The use of carbon monoxide in the transition metal catalysed coupling of amines has led to a powerful methodology for amide bond formation and this is complemented by the addition of an aryl or alkenyl group to an amide typically using palladium or copper catalysts. Amides can be prepared from a wide range of precursors with the aid of metal catalysts.
Bibliography:Liana Allen was born near Manchester, UK. She received her Masters in Chemistry for Drug Discovery at the University of Bath and is currently a PhD candidate at the same university under the supervision of Prof. Jonathan Williams. Liana's current research interests are developing novel, efficient, Lewis acid catalysed syntheses of amide bonds and applying them to the synthesis of pharmaceutical molecules.
Jonathan Williams was born in Stourbridge, England in 1964. He received a BSc from University of York, a DPhil. from University of Oxford (with Prof. S G Davies), and was then a post-doctoral fellow at Harvard with Prof. D. A. Evans (1989-1991). He was appointed to a Lectureship in Organic Chemistry at Loughborough University in 1991, and was then appointed as a Professor of Organic Chemistry at the University of Bath in 1996, where his research has mainly involved the use of transition metals for the catalysis of organic reactions.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0306-0012
1460-4744
DOI:10.1039/c0cs00196a