Percutaneous aortic valve replacement in a 65-year old patient with thalassemia intermedia: A case report

• Published in: Transfusion and apheresis science Vol. 43; no. 2; pp. 189 - 192
• Main Authors: Rosso, Rosamaria, Ussia, Gian Paolo, Ximenes, Benedetta, Tamburino, Corrado, Lombardo, Turiddu
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2010
• Subjects: Aged; Aortic Valve - pathology; Aortic Valve Stenosis - complications; Aortic Valve Stenosis - therapy; beta-Thalassemia - complications; beta-Thalassemia - therapy; Cardiology - methods; Cardiomyopathies - therapy; Health technology assessment; Heart Valve Prosthesis; Hematology, Oncology and Palliative Medicine; Humans; Iron Overload - therapy; Male; Myocardium - pathology; Treatment Outcome
• ISSN: 1473-0502; 1878-1683
• DOI: 10.1016/j.transci.2010.07.003

Abstract Thalassaemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia. Organ damage caused by iron overload represents the major cause of illness and the heart complications secondary to extensive myocardial iron overload are the leading cause of mortality. These patients are generally not considered as candidates for heart transplantation. We report a case of a patient with thalassemia intermedia (TI) with severe cardiac dysfunction and severe aortic stenosis who underwent percutaneous aortic valve replacement (PARV). PARV was a safe and a valid therapeutic approach dramatically to improve the clinical evolution of cardiomyopathies in our patient.