Clinical and radiographic predictors in diagnosing sputum smear- negative pulmonary tuberculosis in HIV-negative patients： a cross- sectional study in China

• Published in: Chinese medical journal Vol. 126; no. 19; pp. 3662 - 3667
• Main Authors: Li, Xin-xu, Jiang, Shi-wen, Zhang, Hui, Jing, Kuan-he, Wang, Li, Li, Wei-bin, Liu, Xiao-qiu, Yao, Hong-yan, Wang, Li-xia
• Format: Journal Article
• Language: English
• Published: China National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China%Chongqing Institution of Tuberculosis Prevention and Treatment,Chongqing 400050, China%Liaoning Center for Disease Control and Prevention, Shenyang 110005, China 05.10.2013
• Subjects: Adult; China; Cross-Sectional Studies; Female; HIV Seronegativity; Humans; Logistic Models; logistic回归模型; Male; Middle Aged; Sputum - microbiology; Tuberculosis, Pulmonary - diagnosis; 中国; 临床; 影像学; 肺结核; 诊断; 阴性; 预测因子; China; validation study; smear negative; tuberculosis; pulmonary/radiography
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20122778

Background In county-level tuberculosis （TB） dispensaries in China,the accurate diagnosis of sputum smear-negative pulmonary tuberculosis （SNPT） needs to be improved by developing and validating clinical and radiographic predictors.Methods The study was conducted simultaneously in three counties per province in Chongqing Municipality and Liaoning Province in China between May 2005 and May 2006.A total of 432 new SNPT patients who are HIV-negative and more than 15 years old diagnosed by expert panels in county-level TB dispensaries were recruited.Their sputum samples were collected for culture before anti-TB treatment,and the treatment outcomes （changes of X-rays） were followed up at the end of the 6th month.Results Of the 432 SNPT patients,sputum culture positive （9.7%） or culture negative with good changes of X-rays at the end of the 6th month （73.6%） was validated as SNPT.Four predictive variables were associated with validated SNPT in the multivariate logistic regression model：age ≤55 years old （odds ratio （OR） 5.66; 95% CI 2.69-11.91）,〉60 days of cough （OR 3.73; 95% CI 1.10-12.65）,≥10% of pulmonary consolidation in the lungs （OR 5.40; 95% CI 2.90-10.06）,and pulmonary consolidation in the upper lobe anterior segment （OR 3.00; 95% CI 1.57-5.72）.The area under the receiver operating characteristic curve of the model was 0.77 （95% CI 0.71-0.83）.Conclusion Four predictors of clinical and radiological characteristics that had a good diagnostic performance of SNPT deserve to be recommended as index indicators of SNPT diagnosis in county-level TB dispensaries in China.