P50 changes with visual interference in normal subjects: a sensory distraction model for schizophrenia

Twenty-five normal subjects were tested in a Conditioning-Testing (S1-S2) auditory P50 study. Each subject was tested twice under two experimental conditions: distraction condition (with light interference) and control condition (without interference). Results showed that S1 P50 amplitude was signif...

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Bibliographic Details
Published inClinical EEG electroencephalography Vol. 27; no. 3; p. 151
Main Authors Jin, Y, Potkin, S G
Format Journal Article
LanguageEnglish
Published United States 01.07.1996
Subjects
Acoustic Stimulation
Adult
Arousal - physiology
Attention - physiology
Evoked Potentials, Auditory - physiology
Evoked Potentials, Visual - physiology
Female
Fourier Analysis
Humans
Male
Photic Stimulation
Reference Values
Schizophrenia - diagnosis
Schizophrenia - physiopathology
Signal Processing, Computer-Assisted
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Summary:Twenty-five normal subjects were tested in a Conditioning-Testing (S1-S2) auditory P50 study. Each subject was tested twice under two experimental conditions: distraction condition (with light interference) and control condition (without interference). Results showed that S1 P50 amplitude was significantly decreased with visual interference compared with that in the control condition, while the S2 response remained unchanged. Consequently, the S2/S1 gating ratio was also increased remarkably in the distraction condition. The auditory EP changes with the visual distraction in normals closely resembled the abnormal findings in schizophrenic subjects. These data may provide an alternative model to elucidate the psychophysiological mechanism that possibly rules the changes of attention in schizophrenia.
ISSN:0009-9155
DOI:10.1177/155005949602700308