Hydrogen abstraction from neurotransmitters by active oxygen species facilitated by intramolecular hydrogen bonding in the radical intermediates

The reactivity of neurotransmitters toward hydrogen abstraction by an active oxygen species (the cumylperoxyl radical) is comparable to that of a strong antioxidant such as catechin due to the strong intramolecular hydrogen bonding, which has been successfully detected by ESR.

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 4; no. 6; p. 999
Main Authors Ohkubo, Kei, Moro-oka, Yoshihiko, Fukuzumi, Shunichi
Format Journal Article
LanguageEnglish
Published England 01.01.2006
Subjects
Electron Spin Resonance Spectroscopy
Free Radicals
Hydrogen
Hydrogen Bonding
Kinetics
Models, Molecular
Neurotransmitter Agents - chemistry
Reactive Oxygen Species - chemistry
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Summary:The reactivity of neurotransmitters toward hydrogen abstraction by an active oxygen species (the cumylperoxyl radical) is comparable to that of a strong antioxidant such as catechin due to the strong intramolecular hydrogen bonding, which has been successfully detected by ESR.
ISSN:1477-0520
DOI:10.1039/b600111d