Phytochemical Profile, Antilipase, Hemoglobin Antiglycation, Antihyperglycemic, and Anti-Inflammatory Activities of Solanum elaeagnifolium Cav

• Published in: Applied sciences Vol. 13; no. 20; p. 11519
• Main Authors: Bouslamti, Mohammed, Elrherabi, Amal, Loukili, El Hassania, Noman, Omar M., Mothana, Ramzi A., Ibrahim, Mansour N., Abdnim, Rhizlan, Slighoua, Meryem, Bouhrim, Mohamed, Bnouham, Mohamed, Lyoussi, Badiaa, Benjelloun, Ahmed Samir
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2023
• Subjects: Antidiabetics; antiglycation; antihyperglycemic; Cytokines; Diabetes; Flowers & plants; fruits; Glucose; Hemoglobin; HPLC; Inflammation; Insulin; Leaves; lipase; Metabolism; Sensors; Solanum elaeagnifolium; Temperature
• ISSN: 2076-3417; 2076-3417
• DOI: 10.3390/app132011519

In the present investigation, the phenolic compounds of Solanum elaeagnifolium were identified, and the plant’s anti-lipase and anti-glycation effects on hemoglobin were discovered through in vitro experiments, as well as its short-term antihyperglycemic and anti-inflammatory effects. The chemical compound composition was detected using HPLC-DAD, the anti-lipase activity was tested in vitro using 4-nitrophenyl butyrate as a substrate, and the antiglycation activity of the plant extracts was also tested in vitro using a haemoglobin model. The antihyperglycemic effect was determined by inhibiting pancreatic α-amylase and α-glycosidase activity and performing an in vivo glucose tolerance test on normal rats, and the anti-inflammatory activity was determined by inducing paw inflammation with carrageenan. In both the SEFR (fruit) and SEFE (leaf) extracts, chromatographic analysis revealed the presence of quercetin 3-O-β-D-glucoside, rutin, and quercetin. SEFR inhibited the pancreatic lipase enzyme more effectively, with an IC50 of 0.106 ± 0.00 mg/mL. S. elaeagnifolium extracts demonstrated significant antiglycation activity, with 3.990 ± 0.23 mg/mL of SEFE and 3.997 ± 0.14 mg/mL of SEFR. When compared to positive and negative controls, plant extracts had very significant anti-diabetic and anti-inflammatory effects. The findings in this study and previous research on this plant encourage us to investigate other pharmacological activities of this plant besides its duiretic, cictrisant, and anti-ulcer activity.