Phenylpropanolamine toxicosis in dogs: 170 cases (2004–2009)

• Published in: Journal of the American Veterinary Medical Association Vol. 239; no. 11; pp. 1463 - 1469
• Main Authors: Peterson, Katherine L, Lee, Justine A, Hovda, Lynn R
• Format: Journal Article
• Language: English
• Published: United States 01.12.2011
• Subjects: agitation; Animals; breathing; Dog Diseases - chemically induced; Dog Diseases - mortality; Dogs; Dose-Response Relationship, Drug; erythema; Female; hypertension; Length of Stay; Male; overdose; patients; phenylpropanolamine; Phenylpropanolamine - poisoning; Poison Control Centers - statistics & numerical data; poisoning; Prognosis; Retrospective Studies; Survival Analysis; survival rate; Sympathomimetics - poisoning; vomiting
• ISSN: 0003-1488; 1943-569X
• DOI: 10.2460/javma.239.11.1463

Objective-To evaluate signalment, clinical signs, dose ingested, treatment requirements, duration of hospitalization, and outcome of dogs exposed to phenylpropanolamine. Design-Retrospective case series. Animals-170 dogs with potential PPA toxicosis evaluated between 2004 and 2009. Procedures-Dogs with potential PPA toxicosis were identified by reviewing the electronic database of an animal poison control center. Results-66 of the 170 (39%) dogs reportedly did not develop any clinical signs. Clinical signs reported in the remaining 104 (61%) dogs included agitation (n = 40), vomiting (27), mydriasis (19), lethargy (17), tremor or twitching (16), panting (15), bradycardia (13), tachycardia (12), hypertension (11), and erythema (8). Median dose ingested for all dogs was 29 mg/kg (13.2 mg/lb). Dogs developing clinical signs had a significantly higher median dose ingested (373 mg/kg [170 mg/lb]) than did dogs that did not develop clinical signs (18 mg/kg [8.2 mg/lb]). Likewise, median dose ingested for the 123 dogs treated as inpatients (36.9 mg/kg [16.8 mg/lb]) was significantly higher than the median dose for the 14 dogs treated as outpatients (20.5 mg/kg [9.3 mg/lb]). Median duration of hospitalization was 18 hours (range, 4 to 72 hours), and hospitalization time increased as the dose ingested increased. Survival rate was 99.4% (169/170); the dog that died had ingested a dose of 145 mg/kg (65.9 mg/lb). Conclusions and Clinical Relevance-Results suggested that with supportive care, the prognosis for dogs that had ingested an overdose of phenylpropanolamine was excellent.