Preparation, relaxometry, and biokinetics of PEGylated magnetoliposomes as MR contrast agent

• Published in: Journal of magnetism and magnetic materials Vol. 194; no. 1; pp. 204 - 209
• Main Authors: Bulte, Jeff W.M., Cuyper, Marcel de, Despres, Daryl, Frank, Joseph A.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 1999; Elsevier Science
• Subjects: Biological and medical sciences; Cells; Contrast agent; Contrast media. Radiopharmaceuticals; Drug therapy; Investigative techniques, diagnostic techniques (general aspects); Iron oxides; Liposome; Magnetic relaxation; Magnetic resonance imaging; Medical sciences; Miscellaneous. Technology; MR imaging; Paramagnetism; Pharmacology. Drug treatments; Polyethylene glycols; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Superparamagnetic iron oxide; Liposome; MR imaging; Superparamagnetic iron oxide; Contrast agent; Iron oxide; Intravenous administration; Rat; Magnetic relaxation; Controlled release form; Rodentia; Superparamagnetism; Experimental study; Nuclear magnetic resonance imaging; Vertebrata; Mammalia; Magnetic material; Animal; Preparation; Bone marrow; Pharmacokinetics; Contrast media; Biomedical engineering
• ISSN: 0304-8853
• DOI: 10.1016/S0304-8853(98)00556-3

We prepared PEGylated magnetoliposomes (ML-PEG) with a diameter of 40 nm and containing 1–6 superparamagnetic iron oxide crystals per vesicle. The T1 and T2 relaxivities were 3 and 240 s −1/mM at 1.5 T and 37°C. In rats, ML-PEG showed a biexponential clearance with a long blood half-life of 53.2±13.2 min. Using MR imaging, ML-PEG was found to have excellent properties as a bone marrow-seeking MR contrast agent.