Effects of thermal water on skin regeneration
An experimental study was carried out in an animal (New Zealand white rabbit) wound model to evaluate any effects of a hypotonic, bicarbonate-calcium-magnesium mineral water (Comano thermal water) on skin regeneration, comparing the healing rate of split-thickness skin graft donor sites treated with...
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Published in | International journal of molecular medicine Vol. 29; no. 5; pp. 732 - 740 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Greece
D.A. Spandidos
01.05.2012
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Subjects | |
Online Access | Get full text |
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Summary: | An experimental study was carried out in an animal (New Zealand white rabbit)
wound model to evaluate any effects of a hypotonic, bicarbonate-calcium-magnesium
mineral water (Comano thermal water) on skin regeneration, comparing the healing
rate of split-thickness skin graft donor sites treated with the thermal water
wet dressing versus a standard petrolatum gauze dressing versus a saline solution
wet dressing. The study was performed in two steps; an overall of 22 animals were
enrolled in the study. The wound healing progress was evaluated both by the surgeons
and by the histologists. Sixty-four punch biopsies were examined in all. The histological
samples were examined after staining with haematoxylin and eosin, Masson's and
orcein staining and under a transmission electron microscope. The data were statistically
analysed. The Comano thermal water proved to improve skin regeneration, not only
by increasing keratinocyte proliferation and migration but also favourably modulating
the regenerated collagen and elastic fibres in the dermis. We propose that the
results of the topical treatment with the thermal water could be due to the favourable
combination of a local wet environment with an anti-inflammatory action and that
the regenerative properties of Comano thermal water observed in rabbits could
also be applied for human use. |
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ISSN: | 1107-3756 1791-244X |
DOI: | 10.3892/ijmm.2012.917 |