Aggression of psychiatric patients associated with the use of as-needed medication

• Published in: Pharmacopsychiatry Vol. 40; no. 1; p. 25
• Main Authors: Goedhard, L E, Stolker, J J, Nijman, H L I, Egberts, A C G, Heerdink, E R
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2007
• Subjects: Adult; Aggression - drug effects; Aggression - psychology; Female; Humans; Male; Mental Disorders - complications; Mental Disorders - drug therapy; Mental Disorders - psychology; Prospective Studies; Psychiatric Status Rating Scales; Psychotropic Drugs - administration & dosage; Psychotropic Drugs - therapeutic use; Treatment Outcome
• ISSN: 0176-3679
• DOI: 10.1055/s-2007-961817

Previous studies showed that aggression is an important reason to prescribe as-needed medication. The objective of this study was to compare the use of as-needed medication in aggressive and non-aggressive psychiatric patients and to explore patterns of administration of as-needed medication around aggressive incidents. An observational study in three psychiatric wards was conducted. Incidence densities of as-needed medication were determined for aggressive and non-aggressive patients and expressed as incidence density ratios [IDRs]. Intensity of as-needed medication used before and following aggressive incidents were determined within a 48-hours time-window. Aggressive patients had an increased use of both psychotropic and somatic as-needed medication (IDR, 2.5; 95% CI, 2.2-2.7 and IDR, 2.1; 95% CI, 1.8-2.4, respectively). Of the psychotropic medication for aggressive patients, 15% was administered in a time-window of 48 hours around an aggressive incident; in this time-window more as-needed medication was administered following an aggressive incident compared to earlier treatments. An increased use of both psychotropic and somatic as-needed medication is associated with aggressive behavior. Psychotropic as-needed medication is more frequently administered shortly after an aggressive incident than shortly before. However, more often as-needed medication is administered outside the 48 hours time-window around an aggressive incident.