Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the v-kit oncogene product and the receptor for macrophage colony stimulating factor (CSF-1). Common structu...

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Bibliographic Details
Published inNature (London) Vol. 323; no. 6085; p. 226
Main Authors Yarden, Y, Escobedo, J A, Kuang, W J, Yang-Feng, T L, Daniel, T O, Tremble, P M, Chen, E Y, Ando, M E, Harkins, R N, Francke, U
Format Journal Article
LanguageEnglish
Published England 18.09.1986
Subjects
Amino Acid Sequence
Animals
Base Sequence
Chromosomes, Human, Pair 5
Cloning, Molecular
DNA - genetics
Humans
Mice
Multigene Family
Platelet-Derived Growth Factor
Protein-Tyrosine Kinases - genetics
Receptors, Cell Surface - genetics
Receptors, Platelet-Derived Growth Factor
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Summary:The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the v-kit oncogene product and the receptor for macrophage colony stimulating factor (CSF-1). Common structural features include the presence of long sequences that interrupt the tyrosine-specific protein kinase domains of each molecule. The PDGF and CSF-1 receptors also share a characteristic distribution of extracellular cysteine residues. Ubiquitin is covalently bound to the purified PDGF receptor, the human gene for which is on chromosome 5.
ISSN:0028-0836
DOI:10.1038/323226a0