Temporal profile of release of interleukin-1β in neurotrauma

• Published in: Neuroscience letters Vol. 284; no. 3; pp. 135 - 138
• Main Authors: Fassbender, Klaus, Schneider, Susanne, Bertsch, Thomas, Schlueter, Dirk, Fatar, Marc, Ragoschke, Andreas, Kühl, Sandra, Kischka, Udo, Hennerici, Michael
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 28.04.2000; Elsevier
• Subjects: Biological and medical sciences; Inflammation; Injuries of the nervous system and the skull. Diseases due to physical agents; interleukin 1^b; Interleukin-1β; Medical sciences; Microdialysis; Neurotrauma; Traumas. Diseases due to physical agents; Inflammation; Microdialysis; Interleukin-1β; Neurotrauma; Rat; Cytokine; Rodentia; Central nervous system; Interleukin 1β; Trauma; Vertebrata; Experimental disease; Mammalia; Animal; Release; Brain (vertebrata)
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(00)00977-0

Timing and extent of trauma-induced release of interleukin-1β (IL-1β) in extracellular fluid of the CNS were analyzed. In brain tissue perfusates obtained by in vivo microdialysis a marked release of IL-1β was unexpectedly detected within less than 60 min. At such an early stage of neurotrauma, mRNA expression of IL-1β was detected whereas immunoreactivity for the IL-1β protein was negative. Concentrations of extracellularly secreted IL-1β protein gradually increased, peaked at day 2 and decreased thereafter. Drugs acting on mononuclear phagocytes significantly modulated IL-1β secretion. This so far unrecognized acuity of IL-1β release demonstrated here, may represent a precondition for the orchestrating role of this mediator in the cascade of inflammatory host response.