The Impact of Late Follicular Phase Progesterone Elevation on Cumulative Live Birth Rate and Embryo Quality in 4072 Freeze-All Cycles

Late follicular phase progesterone elevation during in vitro fertilization impedes embryo implantation. It is unclear whether late follicular phase progesterone elevation still has a negative effect on cumulative live births and embryo quality when a freeze-all strategy is adopted. Data from a total...

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Published inJournal of clinical medicine Vol. 11; no. 24; p. 7300
Main Authors Huang, Ling, Huang, Sunxing, Wen, Yangxing, Zhang, Xiubing, Hu, Xiaokun, Wu, Rihan, Chen, Minghui, Zhou, Canquan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.12.2022
MDPI
Subjects
Birth rate
Embryos
Endometrium
Gene expression
Hormone replacement therapy
In vitro fertilization
Laboratories
Ovaries
Ovulation
Patients
Regression analysis
United States > US
Chicago Illinois
freeze-all strategy
embryo quality
progesterone level
cumulative live birth rate
ovarian stimulation
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Summary:Late follicular phase progesterone elevation during in vitro fertilization impedes embryo implantation. It is unclear whether late follicular phase progesterone elevation still has a negative effect on cumulative live births and embryo quality when a freeze-all strategy is adopted. Data from a total of 4072 patients were reviewed. All patients used the freeze-all strategy. Multivariate regression analyses were used to assess the association of progesterone levels with both cumulative live birth and embryo quality. There was no significant difference in the cumulative live birth rate between the groups with progesterone level <1.5 ng/mL and ≥1.5 ng/mL. The progesterone level was not associated with cumulative live birth and embryo quality.
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These authors contributed equally to this work.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11247300