Chemical tools to discover and target bacterial glycoproteins

Bacterial protein glycosylation is an important post-translational modification that can distinguish pathogenic bacteria from human cells. This review discusses recent findings in the field of bacterial glycobiology, with a particular focus on the unusual structures of bacterial glycans and their li...

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Published inChemical communications (Cambridge, England) Vol. 47; no. 1; pp. 87 - 11
Main Authors Dube, Danielle H, Champasa, Kanokwan, Wang, Bo
Format Journal Article
LanguageEnglish
Published England 01.01.2011
Subjects
Animals
Anti-Bacterial Agents - pharmacology
Bacteria
Bacteria - drug effects
Bacteria - metabolism
Bacteria - pathogenicity
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
Chemical communication
Glycoproteins - antagonists & inhibitors
Glycoproteins - chemistry
Glycoproteins - metabolism
Glycosylation - drug effects
Humans
Molecular Conformation
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Summary:Bacterial protein glycosylation is an important post-translational modification that can distinguish pathogenic bacteria from human cells. This review discusses recent findings in the field of bacterial glycobiology, with a particular focus on the unusual structures of bacterial glycans and their link to pathogenesis. We then describe how chemical tools can augment the study of this class of biomolecules, offering the potential to unveil novel pathogen-associated targets. Finally, this article highlights recent advances in targeting bacteria with therapeutics based on their unique glycans. Bacterial protein glycosylation is an important post-translational modification that can distinguish pathogenic bacteria from human cells. This review describes how chemical tools can augment the study of bacterial glycoproteins, offering the potential to unveil novel pathogen-associated targets. In addition, this article highlights recent advances in targeting bacteria with therapeutics based on their unique glycans.
Bibliography:Bo Wang started conducting lab-based research as a high school student, when he worked in a lab studying the neuroprotective properties of erythropoietin. In Spring 2009 he joined the Dube lab, where he has focused on targeting the pathogen H. pylori based on its unique glycans. After he graduates from Bowdoin College with Honors in Biochemistry in May 2011, he intends to pursue his MD.
Kanokwan (Paggard) Champasa was born in Thailand and was named a Royal Thai Scholar in 2006. She has conducted undergraduate research in the Dube lab since Spring 2009, where she has focused on metabolic profiling of the bacteria H. pylori's glycoproteins. Upon graduating from Bowdoin College with Honors in Biochemistry in May 2011, she plans to pursue her PhD.
Danielle Dube is an Assistant Professor of Chemistry and Biochemistry at Bowdoin College. She received her PhD in Chemistry from the University of California, Berkeley under the guidance of Professor Carolyn Bertozzi in 2005. She then pursued post-doctoral training with Professor Jennifer Kohler at Stanford University. In 2007 Danielle joined the faculty at Bowdoin College. Her research interests are in the areas of chemical biology and glycobiology, including the development of chemical tools to target, alter, and understand glycosylation. Recent work in the lab has focused on using chemical tools to discover and target bacterial glycoproteins.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc01557a