Rhabdomyolysis

• Published in: Acta clinica belgica (English ed. Online) Vol. 62 Suppl 2; p. 375
• Main Author: Sever, M S
• Format: Journal Article
• Language: English
• Published: England 2007
• Subjects: Acute Kidney Injury - etiology; Aged; Bicarbonates - therapeutic use; Compartment Syndromes - etiology; Crush Syndrome - etiology; Diuretics, Osmotic - therapeutic use; Fluid Therapy; History, 16th Century; Humans; Mannitol - therapeutic use; Oliguria - etiology; Oliguria - therapy; Renal Dialysis; Rhabdomyolysis - diagnosis; Rhabdomyolysis - etiology; Rhabdomyolysis - physiopathology; Rhabdomyolysis - prevention & control; Rhabdomyolysis - therapy; Treatment Outcome
• DOI: 10.1179/acb.2007.084
• ISSN: 1784-3286

Rhabdomyolysis is the disintegration of striated muscles resulting in the release of muscular cell contents into the extracellular fluid. Crush syndrome is systemic manifestations caused by rhabdomyolysis; the most important component of crush syndrome is acute kidney injury. Non-physical and physical causes play a role in the aetiology of rhabdomyolysis. Clinical spectrum varies from asymptomatic elevation in creatine kinase to acute tubular necrosis and multiorgan failure. Myoglobinuria, increased serum creatine kinase level and hyperkalaemia are the most important laboratory parameters. Vigorous hydration with isotonic saline followed by alkaline solutions and mannitol are useful in the treatment of rhabdomyolysis.