Rhabdomyolysis

Rhabdomyolysis is the disintegration of striated muscles resulting in the release of muscular cell contents into the extracellular fluid. Crush syndrome is systemic manifestations caused by rhabdomyolysis; the most important component of crush syndrome is acute kidney injury. Non-physical and physic...

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Bibliographic Details
Published inActa clinica belgica (English ed. Online) Vol. 62 Suppl 2; p. 375
Main Author Sever, M S
Format Journal Article
LanguageEnglish
Published England 2007
Subjects
Acute Kidney Injury - etiology
Aged
Bicarbonates - therapeutic use
Compartment Syndromes - etiology
Crush Syndrome - etiology
Diuretics, Osmotic - therapeutic use
Fluid Therapy
History, 16th Century
Humans
Mannitol - therapeutic use
Oliguria - etiology
Oliguria - therapy
Renal Dialysis
Rhabdomyolysis - diagnosis
Rhabdomyolysis - etiology
Rhabdomyolysis - physiopathology
Rhabdomyolysis - prevention & control
Rhabdomyolysis - therapy
Treatment Outcome
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Summary:Rhabdomyolysis is the disintegration of striated muscles resulting in the release of muscular cell contents into the extracellular fluid. Crush syndrome is systemic manifestations caused by rhabdomyolysis; the most important component of crush syndrome is acute kidney injury. Non-physical and physical causes play a role in the aetiology of rhabdomyolysis. Clinical spectrum varies from asymptomatic elevation in creatine kinase to acute tubular necrosis and multiorgan failure. Myoglobinuria, increased serum creatine kinase level and hyperkalaemia are the most important laboratory parameters. Vigorous hydration with isotonic saline followed by alkaline solutions and mannitol are useful in the treatment of rhabdomyolysis.
ISSN:1784-3286
DOI:10.1179/acb.2007.084