Heterogeneous Enantioselective Hydrogenation of Aromatic Ketones Catalyzed by Cinchona- and Phosphine-Modified Iridium Catalysts

Catalyst support: The first highly enantioselective heterogeneous hydrogenation of aromatic ketones catalyzed by Ir/SiO2 stabilized with Ph3P and modified by a chiral diamine derived from a cinchona alkaloid is described (see scheme). The reaction can be employed for the reduction of a broad range o...

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Published inAngewandte Chemie (International ed.) Vol. 47; no. 48; pp. 9240 - 9244
Main Authors Jiang, He-yan, Yang, Chao-fen, Li, Chun, Fu, Hai-yan, Chen, Hua, Li, Rui-xiang, Li, Xian-jun
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 01.01.2008
WILEY‐VCH Verlag
Wiley
Subjects
alkaloids
asymmetric catalysis
Chemistry
Chemistry, Multidisciplinary
iridium
ketones
Physical Sciences
Science & Technology
supported catalysts
ASYMMETRIC TRANSFER HYDROGENATION
STABILIZED GOLD
RHODIUM
alkaloids
asymmetric catalysis
ketones
supported catalysts
1-PHENYL-1,2-PROPANEDIONE
iridium
NANOPARTICLES
MODIFIED PLATINUM
ETHYL PYRUVATE
HOMOGENEOUS CATALYSIS
METAL
LIGAND
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Summary:Catalyst support: The first highly enantioselective heterogeneous hydrogenation of aromatic ketones catalyzed by Ir/SiO2 stabilized with Ph3P and modified by a chiral diamine derived from a cinchona alkaloid is described (see scheme). The reaction can be employed for the reduction of a broad range of aromatic ketones to the corresponding alcohols with high enantioselectivity.
Bibliography:http://dx.doi.org/10.1002/anie.200801809
This work was financially supported by the National Natural Science Foundation of China (No. 20272037) and the Doctor's Foundation of Education Ministry of China (No. 20030610022). The authors thank Prof. Xian‐Deng Hou for his kind help during the preparation of the manuscript.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200801809