Gamma-glutamyl transpeptidase level is a novel adverse prognostic indicator in human metastatic colorectal cancer

• Published in: Colorectal disease Vol. 15; no. 8; pp. e443 - e452
• Main Authors: He, W.-z., Guo, G.-f., Yin, C.-x., Jiang, C., Wang, F., Qiu, H.-j., Chen, X.-x., Rong, R.-m., Zhang, B., Xia, L.-p.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2013
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase - blood; Antigens, Tumor-Associated, Carbohydrate - blood; Antineoplastic Agents - therapeutic use; biomarker; Biomarkers, Tumor - blood; carcinoembryonic antigen; Carcinoembryonic Antigen - blood; colorectal cancer; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - enzymology; Colorectal Neoplasms - mortality; Female; Gamma-glutamyl transpeptidase; gamma-Glutamyltransferase - blood; Humans; Kaplan-Meier Estimate; L-Lactate Dehydrogenase - blood; Male; Middle Aged; Neoplasm Metastasis - pathology; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Retrospective Studies; carcinoembryonic antigen; colorectal cancer; Gamma-glutamyl transpeptidase; biomarker; prognosis
• ISSN: 1462-8910; 1463-1318
• DOI: 10.1111/codi.12258

Aim Biomarkers have been utilized for prognosis in colorectal cancer; however, relatively few have been identified. We compared the prognostic value of serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma‐glutamyl transpeptidase (GGT) with carcinoembryonic antigen (CEA) and carbohydrate antigen 19‐9 (CA19‐9) in patients with metastatic colorectal cancer (mCRC). Method Blood samples were collected from 239 patients with mCRC presenting between 2005 and 2010 in the Sun Yat‐sen University Cancer Center. Results CEA (P < 0.001), CA19‐9 (P < 0.001), GGT (P < 0.001), ALP (P < 0.001) and LDH (P = 0.001) were statistically significant prognostic factors of overall survival (OS). CEA (P = 0.002) and GGT (P = 0.021) were validated as independent predictors. On univariate analysis, CEA (P = 0.003), CA19‐9 (P = 0.006), GGT (P < 0.001) and ALP (P = 0.001) were statistically significant predictive factors of progression‐free survival (PFS) in patients having first‐line chemotherapy. CEA (P = 0.011) and GGT (P = 0.027) were independent predictors. GGT (P = 0.001), ALP (P = 0.016) and LDH (P = 0.039) levels were correlated with the tumour response rate assessed by CT, whilst CEA (P = 0.724) and CA19‐9 (P = 0.822) were not. There was a statistically significant difference in OS (P < 0.001) and PFS (P < 0.001) among patients who had elevations of both CEA and GGT compared with those in whom only one or neither was elevated. Conclusion Among GGT, LDH and ALP, only GGT plays an independent role with CEA in predicting OS and PFS in mCRC. When coupled with CEA, GGT may lead to improved prognostic predictors.